Ventola, C. L. The antibiotic resistance disaster: phase 1: reasons and threats. P. T. 40, 277–283 (2015).
Payne, D. J., Gwynn, M. N., Holmes, D. J. & Pompliano, D. L. Medication for unhealthy insects: confronting the demanding situations of antibacterial discovery. Nat. Rev. Drug Discov. 6, 29–40 (2007).
Deveson Lucas, D. et al. Emergence of high-level colistin resistance in an Acinetobacter baumannii medical isolate mediated by way of inactivation of the worldwide regulator H-NS. Antimicrob. Brokers Chemother. 62, e02442-17 (2018).
Aitolo, G. L., Adeyemi, O. S., Afolabi, B. L. & Owolabi, A. O. Neisseria gonorrhoeae antimicrobial resistance: previous to give to long term. Curr. Microbiol. 78, 867–878 (2021).
Tacconelli, E. et al. Discovery, analysis, and building of recent antibiotics: the WHO precedence checklist of antibiotic-resistant micro organism and tuberculosis. Lancet Infect. Dis. 18, 318–327 (2018).
Imai, Y. et al. A brand new antibiotic selectively kills Gram-negative pathogens. Nature 576, 459–464 (2019).
Biswas, S., Brunel, J. M., Dubus, J. C., Reynaud-Gaubert, M. & Rolain, J. M. Colistin: an replace at the antibiotic of the twenty first century. Professional Rev. Anti Infect. Ther. 10, 917–934 (2012).
Liu, Y. Y. et al. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular organic learn about. Lancet Infect. Dis. 16, 161–168 (2016).
Jeannot, Okay., Bolard, A. & Plesiat, P. Resistance to polymyxins in Gram-negative organisms. Int. J. Antimicrob. Brokers 49, 526–535 (2017).
Liu, Y. Y. et al. Structural amendment of lipopolysaccharide conferred by way of mcr-1 in Gram-negative ESKAPE pathogens. Antimicrob. Brokers Chemother. 61, e00580-17 (2017).
Schwarz, S. & Johnson, A. P. Transferable resistance to colistin: a brand new however previous danger. J. Antimicrob. Chemother. 71, 2066–2070 (2016).
Hameed, F. et al. Plasmid-mediated mcr-1 gene in Acinetobacter baumannii and Pseudomonas aeruginosa: first file from Pakistan. Rev. Soc. Bras. Med. Trop. 52, e20190237 (2019).
Tian, G. B. et al. MCR-1-producing Klebsiella pneumoniae outbreak in China. Lancet Infect. Dis. 17, 577 (2017).
Rutledge, P. J. & Challis, G. L. Discovery of microbial herbal merchandise by way of activation of silent biosynthetic gene clusters. Nat. Rev. Microbiol. 13, 509–523 (2015).
Sussmuth, R. D. & Mainz, A. Nonribosomal peptide synthesis – rules and potentialities. Angew. Chem. Int. Ed. Engl. 56, 3770–3821 (2017).
Stachelhaus, T., Mootz, H. D. & Marahiel, M. A. The specificity-conferring code of adenylation domain names in nonribosomal peptide synthetases. Chem. Biol. 6, 493–505 (1999).
Rabanal, F. & Cajal, Y. Contemporary advances and views within the design and building of polymyxins. Nat. Prod. Rep. 34, 886–908 (2017).
Li, J., Country, R. & Kaye, Okay. (eds) Polymyxin Antibiotics: From Laboratory Bench to Bedside Preface 1145, V–VI (Springer, 2019).
Tomm, H. A., Ucciferri, L. & Ross, A. C. Advances in microbial culturing prerequisites to turn on silent biosynthetic gene clusters for novel metabolite manufacturing. J. Ind. Microbiol. Biotechnol. 46, 1381–1400 (2019).
Chu, J. et al. Discovery of MRSA lively antibiotics the use of number one collection from the human microbiome. Nat. Chem. Biol. 12, 1004–1006 (2016).
Chu, J., Vila-Farres, X. & Brady, S. F. Bioactive synthetic-bioinformatic herbal product cyclic peptides impressed by way of nonribosomal peptide synthetase gene clusters from the human microbiome. J. Am. Chem. Soc. 141, 15737–15741 (2019).
Chu, J. et al. Artificial-bioinformatic herbal product antibiotics with numerous modes of motion. J. Am. Chem. Soc. 142, 14158–14168 (2020).
Kang, Okay. N. et al. Colistin heteroresistance in Enterobacter cloacae is regulated by way of PhoPQ-dependent 4-amino-4-deoxy-l-arabinose addition to lipid A. Mol. Microbiol. 111, 1604–1616 (2019).
McClerren, A. L. et al. A sluggish, tight-binding inhibitor of the zinc-dependent deacetylase LpxC of lipid A biosynthesis with antibiotic job related to ciprofloxacin. Biochemistry 44, 16574–16583 (2005).
Moffatt, J. H. et al. Colistin resistance in Acinetobacter baumannii is mediated by way of entire lack of lipopolysaccharide manufacturing. Antimicrob. Brokers Chemother. 54, 4971–4977 (2010).
Wei, J.-R. et al. LpxK is very important for enlargement of Acinetobacter baumannii ATCC 19606: courting to poisonous accumulation of lipid A pathway intermediates. mSphere 2, e00199–00117 (2017).
Richie, D. L. et al. Poisonous accumulation of LPS pathway intermediates underlies the requirement of LpxH for enlargement of Acinetobacter baumannii ATCC 19606. PLoS ONE 11, e0160918 (2016).
US Division of Well being and Human Services and products. Antibiotic Resistance Threats in america; https://www.cdc.gov/drugresistance/pdf/threats-report/2019-ar-threats-report-508.pdf (2019).
Ling, Z. et al. Epidemiology of cell colistin resistance genes mcr-1 to mcr-9. J. Antimicrob. Chemother. 75, 3087–3095 (2020).
Sakura, N. et al. The contribution of the N-terminal construction of polymyxin B peptides to antimicrobial and lipopolysaccharide binding job. Bull. Chem. Soc. Jpn 77, 1915–1924 (2004).
Tsubery, H., Ofek, I., Cohen, S. & Fridkin, M. N-terminal changes of polymyxin B nonapeptide and their impact on antibacterial job. Peptides 22, 1675–1681 (2001).
Lutgring, J. D. et al. FDA-CDC antimicrobial resistance isolate financial institution: a publicly to be had useful resource to reinforce analysis, building, and regulatory necessities. J. Clin. Microbiol. 56, e01415-17 (2018).
Devarajan, P. Neutrophil gelatinase-associated lipocalin (NGAL): a brand new marker of kidney illness. Scand. J. Clin. Lab. Make investments. Suppl. 241, 89–94 (2008).
Wang, J., Ishfaq, M., Fan, Q., Chen, C. & Li, J. 7-hydroxycoumarin attenuates colistin-induced kidney damage in mice during the reduced point of histone deacetylase 1 and the activation of Nrf2 signaling pathway. Entrance. Pharmacol. 11, 1146 (2020).
Bolignano, D. et al. Neutrophil gelatinase-associated lipocalin (NGAL) as a marker of kidney injury. Am. J. Kidney Dis. 52, 595–605 (2008).
Blin, Okay. et al. The antiSMASH database model 2: a complete useful resource on secondary metabolite biosynthetic gene clusters. Nucleic Acids Res. 47, D625–D630 (2019).
Blin, Okay. et al. antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline. Nucleic Acids Res. 47, W81–W87 (2019).
Trying out, E. C. O. A. S. Suggestions for MIC Choice of Colistin (Polymyxin E) as Beneficial by way of the Joint CLSI-EUCAST Polymyxin Breakpoints Running Crew (EUCAST, 2016).
Wikler, M. A. Strategies for dilution antimicrobial susceptibility assessments for micro organism that develop aerobically: authorized usual. CLSI record M07-A7 (2006).
Bojkovic, J. et al. Characterization of an Acinetobacter baumannii lptD deletion pressure: permeability defects and reaction to inhibition of lipopolysaccharide and fatty acid biosynthesis. J. Bacteriol. 198, 731–741 (2015).
Carmichael, J., DeGraff, W. G., Gazdar, A. F., Minna, J. D. & Mitchell, J. B. Analysis of a tetrazolium-based semiautomated colorimetric assay: evaluation of chemosensitivity trying out. Most cancers Res. 47, 936–942 (1987).
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